Table 2. Comparison of the MIC values and anti-persister activity of selected antibiotics against B. burgdorferi.
| Antibiotics | MIC (μg/mL) | Cmax (μg/mL)a | Activity against persisters |
|---|---|---|---|
| Doxycycline | ≤0.25 | 3.6–4.6 | − |
| Amoxicillin | ≤0.25 | 1.5–13.8 | − |
| Metronidazole | 25 | 12.5–19.4 | − |
| Daptomycin | 12.5–25 | 57.8–93.9 | ++++ |
| Clofazimine | 6.25 | 0.47–0.7 | +++ |
| Carbomycin | ≤0.25 | 0.625 | +++ |
| Cefoperazone | ≤0.25 | 111–375 | +++ |
| Cefotiam | ≤0.25 | 30–170 | ++ |
| Vancomycin | 0.2–0.4 | 19–23 | + |
| Tazobactam | 12.5 | 14.8–33.8 | − |
| Sulfamethoxazole | ≤0.25 | 46.3 | − |
a
Cmax values are derived from the literature.