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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Med Genet. 2014 Mar 24;51(5):327–333. doi: 10.1136/jmedgenet-2013-102151

Table 2.

Top 10 genetic loci associated with smoking initiation (Ever versus never smoker), stratified by sex

Nearest gene Locus SNP marker MA MAF P value
Ever smokers Never smokers
Males
SLC39A11 17q21.31 rs2567519 A 0.39 0.46 1.33 × 10−7
SLC39A11 17q21.31 rs2714017 T 0.39 0.47 1.34 × 10−7
MIR1305||TENM3 4q35.1 rs11724903 G 0.09 0.13 2.90 × 10−7
SLC39A11 17q21.31 rs7406107 G 0.43 0.51 4.32 × 10−7
SLC39A11 17q21.31 rs2714016 A 0.39 0.47 5.06 × 10−7
SLC39A11 17q21.31 rs2714018 A 0.39 0.47 7.49 × 10−7
SLC39A11 17q21.31 rs4793310 C 0.41 0.48 7.67 × 10−7
LINC00607  2q35 rs4674024 A 0.34 0.41 1.52 × 10−6
MAT2B||LOC100419716 5q33 rs292404 G 0.13 0.18 1.72 × 10−6
MAT2B||LOC100419716 5q33 rs10057965 C 0.21 0.26 2.74 × 10−6
Females
PAGE3||MAGEH1 Xp11.21 rs4240023 A 0.07 0.02 7.79 × 10−8
SLCO3A1||ST8SIA2 15q26 rs12912184 A 0.26 0.34 9.32 × 10−8
MIR4536-1  Xp11.21 rs4826404 G 0.07 0.02 9.37 × 10−8
RRAGB||LOC644924 Xp11.21 rs4826434 C 0.07 0.02 1.06 × 10−7
USP51  Xp11.21 rs2499862 A 0.07 0.02 1.20 × 10−7
XAGE-4 Xp11.21 rs4265330 C 0.07 0.02 2.02 × 10−7
SLCO3A1||ST8SIA2 15q26 rs12901615 A 0.26 0.34 2.21 × 10−7
XAGE-4||RRAGB Xp11.21 rs5914419 A 0.07 0.02 2.78 × 10−7
RRAGB||LOC644924 Xp11.21 rs2375467 A 0.07 0.02 2.81 × 10−7
RRAGB||LOC644924 Xp11.21 rs1325570 A 0.07 0.02 2.84 × 10−7

Minor allele, MA; minor allele frequency, MAF.