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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Apr 18;1842(9):1340–1349. doi: 10.1016/j.bbadis.2014.04.012

Figure 1. Schematic of potential risk factors for AD.

Figure 1

We propose that a combination of nuclear and mitochondrially-encoded genes determine one’s baseline risk for AD. This baseline risk can be modified – either increased (+) or decreased (−) by a wide variety of environmental factors, (diet, exercise) socioeconomic factors (i.e. education) and inevitably by the aging process.