Table 5.

Change in CDI among knees with and without structural progression

	Joint Space Narrowing (JSN)
	No structural progression				Structural progression				p-value
	n	Mean	SD	SRM	n	Mean	SD	SRM
Femur CDI (Change)	74	−35.73	50.14	−0.71	25	−87.82	68.62	−1.28	<0.0001
Tibia CDI (Change)	74	−10.86	23.99	−0.45	25	−63.83	46.02	−1.39	<0.0001
Tibiofemoral CDI (Change)	74	−46.58	57.48	−0.81	25	−151.7	90.95	−1.67	<0.0001
	Kellgren-Lawrence (KL)
	No structural progression				Structural progression				p-value
	n	Mean	SD	SRM	n	Mean	SD	SRM
Femur CDI (Change)	58	−40.53	49.84	−0.81	39	−64.06	70.06	−0.91	0.060
Tibia CDI (Change)	58	−15.86	33.21	−0.48	39	−37.23	43.34	−0.86	0.007
Tibiofemoral CDI (Change)	58	−56.39	64.12	−0.88	39	−101.3	96.68	−1.05	0.007

Notes: Structural Progression, JSN/KL has different grade at baseline and follow- up; N = number of knees (the numbers were excluded JSN = 3 and KL = 4 since both of them are the highest grade, no grade change happens); SD = standard deviation; SRM = standardized response mean.