Table 2.
Clinical and radiological factors associated with survival and progression
| Factor | Overall survival median/months | 95% CI | Significance on univariate analysis | Progression free survival median/months | 95% CI | Significance on univariate analysis | |
|---|---|---|---|---|---|---|---|
| GPA score |
|
|
|
|
|
|
|
| < 1.0 |
5.3 |
0.4 – 10.2 |
0.306 |
Not reached |
|
0.936 |
|
| 1.5-2 |
6.8 |
0 – 14.0 |
|
18.4 |
- |
||
| 2.5-3.0 |
9.3 |
8.0 – 10.6 |
|
17.8 |
6.1 – 29.4 |
||
| > 3.0 |
9.8 |
7.8 – 11.7 |
|
13.1 |
9.0 – 17.2 |
||
| RPA class |
|
|
|
|
|
|
|
| I |
14.0 |
6.1 – 22.0 |
0.030* |
17.7 |
14.6 – 20.9 |
0.636 |
|
| II |
8.4 |
5.1 – 11.8 |
13.1 |
9.7 – 16.6 |
|||
| III |
2.0 |
0 – 6.2 |
Not reached |
|
|||
| Primary cancer |
|
|
|
|
|
(too many censored cases in each category for analysis) |
|
| Lung non-small cell |
9.2 |
2.0 – 19.8 |
0.061 |
Not reached |
|
||
| Lung small cell |
4.5 |
1.0 – 28.9 |
|
10.5 |
- |
||
| Breast |
10.4 |
0.9 – 21.2 |
|
9.2 |
5.6 – 12.9 |
||
| Colorectal |
6.8 |
5.3 – 12.3 |
|
Not reached |
|
||
| Melanoma |
11.5 |
2.4 – 14.7 |
|
7.3 |
4.9 – 9.7 |
||
| Urological |
4.0 |
1.1 – 9.6 |
|
Not reached |
|
|
|
| Ovarian |
11.2 |
4.7 – 30 |
|
17.8 |
- |
||
| Unknown |
5.6 |
1.5 – 22.8 |
|
18.4 |
- |
||
| Location |
|
|
|
|
|
|
|
| Supratentorial |
9.6 |
8.2 – 11.1 |
0.070 |
17.7 |
10.8 – 24.6 |
0.872 |
|
| Infratentorial |
4.4 |
0 – 10.1 |
|
Not reached |
|
||
| Surgery |
|
|
|
|
|
|
|
| Biopsy |
5.9 |
0 – 16.4 |
0.091 |
|
|
||
| Resection |
9.6 |
8.1 – 11.0 |
|
|
|
||
| Adjuvant whole brain radiotherapy |
|
|
|
|
|
|
|
| Yes |
10.5 |
8.9 - 12 |
0.000* |
17.7 |
10.9 – 24.6 |
0.000* |
|
| No |
2.4 |
1.5 – 3.3 |
|
Not reached |
|
||
| Adjuvant chemotherapy |
|
|
|
|
|
|
|
| Yes |
10.5 |
8.2 – 12.7 |
0.001* |
15.7 |
10.7 – 20.6 |
0.240 |
|
| No |
5.3 |
3.0 – 7.6 |
|
Not reached |
|
||
| Diffusion MR metrics |
|
|
|
|
|
|
|
| ADCmin > 919 × 10-6 mm2/s |
9.7 |
8.5 – 11.0 |
0.049* |
18.4 |
13.2 – 23.6 |
0.087 |
|
| ADCmin < 919 × 10-6 mm2/s |
6.2 |
3.7 – 8.8 |
|
11.3 |
8.4 – 14.3 |
||
| ADCmean > 1148 × 10-6 mm2/s |
9.7 |
7.9 – 11.5 |
0.093 |
18.4 |
11.6 – 25.1 |
0.039* |
|
| ADCmean < 1148 × 10-6 mm2/s |
6.7 |
4.9 – 8.5 |
|
11.3 |
5.8 – 16.8 |
||
| ATC > 0.279 |
6.8 |
5.3 – 8.4 |
0.041* |
11.3 |
8.2 – 14.4 |
0.072 |
|
| ATC < 0.279 |
11.2 |
8.3 – 14.0 |
|
Not reached |
|
||
| Standard MRI measures |
|
|
|
|
|
|
|
| Diameter > 30 mm |
6.7 |
2.4 – 11.0 |
0.246 |
13.1 |
9.7 – 16.6 |
0.551 |
|
| Diameter < 30 mm |
9.6 |
8.8 – 10.4 |
|
17.8 |
14.7 – 20.1 |
||
| Volume > 8.9 cc |
6.7 |
1.9 – 11.5 |
0.077 |
13.1 |
9.2 – 17.1 |
0.158 |
|
| Volume < 8.9 cc |
9.6 |
8.8 – 10.3 |
|
17.8 |
13.7 – 21.8 |
||
| Solitary |
8.42 |
5.3 – 11.5 |
0.101 |
15.7 |
10.3 – 21.0 |
0.673 |
|
| 2 lesions |
14.1 |
10.7- 17.6 |
|
11.3 |
0.85 – 21.8 |
||
| > 2 lesions | 6.1 | 5.1 – 12.2 | Not reached |
Log rank tests were applied to detect differences between categories with Wilcoxon modification (the Breslow chi square test) in cases where hazard did not appear to be proportional. In all comparisons *indicates p < 0.05.