Figure 1.

Schematic representation of bone remodeling based on BMU activity coupled to mechanical stimulus: at the remodeling cycle (n), the applied load generates mechanical stress, strain, and fatigue damage states at every FE of the mesh. A stimulus is then sensed by osteocytes at every bone site. The stimulus is converted into signals, which control the osteoblast and osteoclast interactions. Bone formation and removal is performed by competition between osteoblast and osteoclast growth at the given bone site.