TABLE 7.
Multivariable analysis of factors predictive of outcome.
| Variable | OS
|
DSS
|
RFS
|
|||
|---|---|---|---|---|---|---|
| (HR) | p value | (HR) | p value | (HR) | p value | |
| Margin status | 2.36 (0.86–6.45) | .09 | 3.23 (1.00–10.49) | .050 | 2.89 (1.12–7.52) | .21 |
| Regional nodal metastasis | 4.67 (1.42–15.36) | .01 | 6.21 (1.78–21.68) | .004 | 5.32 (1.43–19.73) | .01 |
| Previously treated | 1.20 (0.44–3.42) | .72 | 1.19 (0.39–3.66) | .75 | 1.16 (0.46–2.90) | .75 |
| Clinical parotid invasion | 1.39 (0.47–4.74) | .56 | 1.49 (0.16–19.29) | .73 | 1.10 (0.48–2.55) | .81 |
| Clinical middle ear invasion | 1.75 (0.99–3.14) | .05 | 3.43 (0.90–13.12) | .07 | 1.77 (1.04–3.00) | .03 |
| Clinical intracranial extension | 1.45 (0.80–2.62) | .23 | 2.51 (0.73–8.67) | .14 | 1.42 (0.82–2.45) | .21 |
| Clinical mandible invasion | 2.86 (1.58–5.21) | .001 | 3.25 (1.73–6.09) | <.0001 | 2.09 (1.13–3.83 | .02 |
| Advanced cT classification* | 1.14 (0.66–1.94) | .65 | 1.32 (0.68–2.15) | .41 | 1.67 (0.87–3.19) | .12 |
| Pathologic bone invasion | 2.53 (0.80–8.00) | .11 | 4.96 (1.07–23.07) | .04 | 1.55 (0.55–4.34) | .41 |
| Pathologic parotid invasion | 10.98 (1.66–72.67) | .01 | 10.11 (1.47–69.48) | .02 | 6.37 (1.71–23.72) | .006 |
| Perineural invasion | 1.15 (0.28–4.76) | .85 | 1.71 (0.33–8.81) | .52 | 2.17 (0.72–6.62) | .17 |
| Depth of invasion >1 mm | 1.17 (0.24–3.07) | .81 | 2.30 (0.49–10.85) | .29 | 1.05 (0.31–3.63) | .93 |
| Advanced pT classification* | 1.17 (0.80–1.72) | .43 | 1.32 (0.79–2.13) | .28 | 1.65 (1.01–2.73) | .049 |
| Craniotomy performed | 3.82 (1.42–10.20) | .007 | 4.34 (1.47–12.80) | .008 | 2.06 (0.73–5.60) | .16 |
| Facial nerve sacrificed | 2.67 (1.01–7.07) | .048 | 3.29 (1.04–10.42) | .04 | 2.15 (0.87–5.32) | .09 |
| Postoperative radiation | 1.64 (0.89–3.03) | .11 | 1.51 (0.76–3.13) | .25 | 1.61 (0.93–2.78) | .75 |
Abbreviations: OS, overall survival; DSS, disease-specific survival; RFS, recurrence-free survival; HR, hazard ratio.
*
Advanced: T3–T4.