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. 2014 Apr 22;3:93. [Version 1] doi: 10.12688/f1000research.3720.1

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Copyright: © 2014 Fameli N et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).

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Figure 4. — A, Snapshot from a TEM tomogram of a L-SR region of rat pulmonary artery smooth muscle, illustrating, among other things, a single SR extension apparently forming junctions with several lysosomes. Magnification: 62,000×. B, Same snapshot shown in A, but with a lysosome (orange) and a portion of SR (turquoise) partially traced out in 3D. These pseudocolour tracings underscore how the SR can appear as a large cistern in a given plane, but can actually branch out in different directions when viewed in 3D. Scale bars ≈ 100 nm.