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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Mar 9;3(3):229–246. doi: 10.1002/wnan.136

Figure 3.

Figure 3

a) Illustration of a mechanical cantilever resonator containing an embedded microfluidic channel. b) Illustration showing a decrease in resonant frequency as the density inside the embedded channel. If molecules that selectively bind to the channel walls are present, they will accumulate in the channel, causing an increased density in the channel that can be detected as a frequency shift. c) If a single particle is cycled through the channel, it will cause a frequency shift that varies with the particle’s position along the cantilever. This allows the measurement of the mass of single, isolated, unbound particles in solution.71 Reprinted by permission from Macmillan Publishers Ltd: Nature. Burg TP, Godin M, Knudsen SM, Shen W, Carlson G, Foster JS, Babcock K, Manalis SR. Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 2007, 446:1066–1069. Copyright 2007.