Table 4. Sensitivities, specificities, positive and negative predictive values and kappa analysis.
Fever patients ABI-extracted DNA (n = 865) | |||||
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Kappa value | |
Pan-LAMP | 91.5 (84.8–95.8) | 100 (99.5–100) | 100 (96.6–100) | 98.7 (97.6–99.4) | 0.95 |
Pf-LAMP | 86.3 (78.7–92.0) | 100 (99.5–100) | 100 (96.4–100) | 97.9 (96.6–98.8) | 0.92 |
P.f.* = P. falciparum mono infections (n = 33), P.m.** = P.malariae mono infections (n = 13), P.f.*** P. falciparum mono and mixed.
infections (n = 41), CI = confidence interval, PPV = positive predictive value, NPV = negative predictive value.
Sensitivities, specificities, positive and negative predictive values and kappa analysis for detection of malaria DNA from fever patients and asymptomatic individuals with Pan and Pf-LAMP versus gold standard (real- time PCR corrected Cytochrome b nested PCR).