Table 2. Effect of rs28365859 genotype and genotype-by-diagnosis interaction on gray matter volume.

	Brain region	Contrast	Covariates	Talairach coordinate			Cluster size	p
				x	y	z
Interaction on whole brain
	Rt putamen		age, sex	32	13	−5	125	<0.0001 (uncorrected)
	Lt insula		age, sex	−39	10	−11	108	<0.0001 (uncorrected)
Interaction on SVC
	Rt putamen		age, sex	32	13	−5	168	0.001 (FWE-corrected)
	Lt insula		age, sex	−39	10	−11	232	0.004 (FWE-corrected)
Genotype effect on SVCa
	Rt putamen	ConC−>ConC+	age, sex	30	16	−1	60	0.023 (FWE-corrected)
	Lt insula	SzC+>SzC−	age, sex	−36	8	−11	52	0.047 (FWE-corrected)
		SzC+>SzC−	age, sex, doi,med	−36	8	−11	68	0.037 (FWE-corrected)

ConC+, controls with C allele; ConC−, controls without C allele; doi, duration of illness; FWE, family-wise error; Lt, left; med, daily medication dose; Rt, right; SVC, small volume correction; SzC+, schizophrenia patients with C allele; SzC−, schizophrenia without C allele.

^aThere were no suprathreshold clusters for other contrasts.