Table 1. Criteria for the search strategy used in drug target rankings.
| Criteria (default weighting) | Weighting |
| FPKM1 > 10 in each tissue | 0.1 |
| Essentiality2 | 0.1 |
| Drug literature: hit to ChEMBL | 0.25 |
| Drug literature: druggable in ChEBML | 0.75 |
| Drug literature: tractable in ChEBML | 0.25 |
| DrugBank: hit to DrugBank approved list | 1 |
| No DrugBank approved target, although clinical data are available | 0.25 |
| TTD: protein is orthologous to TTD-successful target | 1 |
| TTD: No TTD-successful target but matches compound target | 0.25 |
| Lead compound found | 1 |
| The protein is a GPCR or a protein kinase | 1 |
| No lead compound but presence of drug domain | 0.2 |
1
FPKM represents Fragments Per Kilobase of transcript per Million mapped reads.
2
Essentiality, lethal phenotype in mouse ortholog knockout or lethal were considered indicative of essential genes in tree shrew.