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. 2014 Aug 8;9(8):e104557. doi: 10.1371/journal.pone.0104557

Table 4. Sensitivity analysis for effectiveness of IPT with or without ART using Cox proportional hazards model among patients on ART assuming those who were lost to follow-up and dead developed TB in SNNP region, Ethiopia, September 2007 to August 2010.

Category Sub-category Incident TB+lost+dead Person-years Incidence rate per 100 person-years Unadjusted HR (95% CI) Adjusted HR (95% CI)
IPT and/or ART * No intervention 93 1018 9.1 1 1
IPT only 9 370 2.4 0.36 (0.18–0.71) 0.40 (0.20–0.80)
IPT before ART 15 682 2.2 0.42 (0.24–0.74) 0.45 (0.25–0.80)
ART only 266 3832 6.9 0.93 (0.73–1.19) 0.69 (0.53–0.89)
IPT & ART Simultaneously 14 558 2.5 0.39 (0.22–0.70) 0.35 (0.20–0.62)
IPT after ART 41 2713 1.5 0.30 (0.20–0.46) 0.22 (0.15–0.34)

*Controlled for sex, WHO stage, cotrimoxazole use, and baseline CD4; HR-Hazard Ratio; CI- Confidence Interval; IPT-Isoniazid Preventive Therapy; ART-antiretroviral therapy; WHO-World Health Organization; HIV-Human Immunodeficiency virus.