Table 4. Sensitivity analysis for effectiveness of IPT with or without ART using Cox proportional hazards model among patients on ART assuming those who were lost to follow-up and dead developed TB in SNNP region, Ethiopia, September 2007 to August 2010.
Category | Sub-category | Incident TB+lost+dead | Person-years | Incidence rate per 100 person-years | Unadjusted HR (95% CI) | Adjusted HR (95% CI) |
IPT and/or ART * | No intervention | 93 | 1018 | 9.1 | 1 | 1 |
IPT only | 9 | 370 | 2.4 | 0.36 (0.18–0.71) | 0.40 (0.20–0.80) | |
IPT before ART | 15 | 682 | 2.2 | 0.42 (0.24–0.74) | 0.45 (0.25–0.80) | |
ART only | 266 | 3832 | 6.9 | 0.93 (0.73–1.19) | 0.69 (0.53–0.89) | |
IPT & ART Simultaneously | 14 | 558 | 2.5 | 0.39 (0.22–0.70) | 0.35 (0.20–0.62) | |
IPT after ART | 41 | 2713 | 1.5 | 0.30 (0.20–0.46) | 0.22 (0.15–0.34) |
*Controlled for sex, WHO stage, cotrimoxazole use, and baseline CD4; HR-Hazard Ratio; CI- Confidence Interval; IPT-Isoniazid Preventive Therapy; ART-antiretroviral therapy; WHO-World Health Organization; HIV-Human Immunodeficiency virus.