Table 1. Patients characteristics at baseline.

		Evaluable patients (n = 53)
Characteristic		n (%)
Age (years)	Median	59
	Range	20–79
	<70 years	42 (79)
	≥70 years	11 (21)
Sex	Male	42 (79)
	Female	11 (21)
Baseline ECOG performance status	0	12 (23)
	1	27 (51)
	2	13 (24)
	3	1 (2)
N. of Argiris factors	0–2	14 (26)
	≥3	39 (74)
Weight loss	<5%	29 (55)
	≥5%	24 (45)
Alcohol abuse	Yes	26 (49)
	No	27 (51)
Smoking history	Yes	46 (87)
	No	7 (13)
Anatomic distribution of primary tumor	Nasopharynx	4 (8)
	Nasal sinus	4 (8)
	Oral cavity	17 (32)
	Oropharynx	7 (13)
	Hypopharynx	4 (8)
	Larynx	15 (28)
	Cervical esophagus	2 (3)
Tumor grade	1–2	44 (83)
	3	9 (17)
Disease extent	Locally advanced	26 (49)
	Metastatic	27 (51)
No of disease sites	1	30 (56)
	2	20 (38)
	3	2 (4)
	4	1 (2)
Prior treatments for primary tumor	Surgery	32 (60)
	Radiotherapy	34 (64)
	Chemotherapy	15 (28)
N. of prior chemotherapy lines for metastatic disease	0	40 (75)
	1	7 (13)
	2	1 (2)
	3	5 (10)