Table 3.

Risk of Hospital Mortality in Subjects With CIRCI, Non-Responsiveness to Cosyntropin

	Crude Relative Risk (95% CI) for Hospital Mortality	Adjusted Relative Risk (95% CI) for Hospital Mortality*
CIRCI vs no CIRCI (reference group)†	1.32 (1.08–1.61)	1.31 (1.07–1.59)
Non-responders‡ vs responders (reference group)§	1.68 (1.38–2.05)	1.57 (1.29–1.92)
Adjusted for hypoproteinemia (albumin ≤ 2.5 g/dL)
CIRCI vs no CIRCI (reference group)		1.44 (1.18–1.77)
Non-responders vs responders (reference group)		1.64 (1.34–2.00)

^*All analyses adjusted for age, sex, and Simplified Acute Physiology Score (SAPS II).

^†In this comparison, 52 subjects had baseline cortisol of ≥ 10 μg/dL and Δ max of ≤ 9 μg/dL but were missing their 60-min post-stimulation results, precluding definitive diagnosis of CIRCI. We omitted those subjects. Including them by using their 30-min result provided an adjusted relative risk of 1.23 (95% CI 1.02–1.48).

^‡Non-responsiveness was defined as a Δ max of ≤ 9 μg/dL following administration of cosyntropin.

^§In this comparison, 57 subjects had 30-min results ≤ 9 μg/dL but were missing data for their 60-min post-stimulation reading, precluding definitive diagnosis of non-responsiveness. We omitted those subjects. Including them by using their 30-min result provided an adjusted relative risk of 1.56 (95% CI 1.29–1.89)

CIRCI = critical illness-related corticosteroid insufficiency, defined as a random total cortisol < 10 μg/dL and/or a Δ max cortisol following cosyntropin administration of < 9 μg/dL