Table 3.

Pathway Set-Test Results for Main Effects Within the VEGF Signaling Pathway (894 SNPs) for 1207 Cases and 686 Controls Who Had a History of Smoking and/or Exogenous Estrogen Use

Individuals With Data On:	Total AMD Dataset*	Neovascular AMD Subset†
	P Value	P Value
Smoking	0.27	0.083
HRT‡	0.59	0.12
BCPs‡	0.70	0.2

^* The total AMD dataset denotes grades 3, 4, and 5 (cases) versus grades 1 and 2 (controls).

^† The neovascular AMD subset denotes grade 5 (cases) versus grade 1 (controls).

^‡ Dataset includes women only.