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. Author manuscript; available in PMC: 2015 Feb 7.
Published in final edited form as: Nature. 2014 Jun 29;512(7512):69–73. doi: 10.1038/nature13322

Figure 1. Il1r1-deficiency rescues the arthritis phenotype of A20myel-KO mice.

Figure 1

a, b, A20 and β-actin mRNA (a) and protein (b) levels of LPS-stimulated BMDMs. c, Hind paws of 20 weeks old mice. d, e, A20fl/flIL1R1+/+ (n=19), A20myel-KOIL1R1+/+ (n=8), A20myel-KOIL1R1+/− (n=15) and A20myel-KOIL1R1−/− (n=9) mice aged 21-30 weeks were clinically scored for arthritis incidence (d) and severity (e). f, Ankle joints sections stained with haematoxylin and eosin; magnification: 40× (top) and 100x (bottom). g, Histological scores of ankle sections of A20myel-KOIL1R1+/− (n=10) and A20myel-KOIL1R1−/− (n=8). P-values in e and g were determined by Student’s t-test.