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. Author manuscript; available in PMC: 2015 Feb 7.
Published in final edited form as: Nature. 2014 Jun 29;512(7512):69–73. doi: 10.1038/nature13322

Figure 4. Nlrp3 and caspase-1 deletion rescues arthritis in A20myel-KO mice.

Figure 4

a, IL1β serum levels of A20fl/flNlrp3+/+ (n=10), A20myel-KONlrp3+/+ (n=10) and A20myel-KONlrp3−/− (n=10) mice aged 20-35 weeks. b, Hind paws of 30 weeks old mice. c, d, A20myel-KONlrp3+/+ (n = 20) and A20myel-KONlrp3−/−(n=17) mice were scored for arthritis incidence (d) and severity (e). e, Representative ankle joints sections; magnification: 40× (top) and 100x (bottom). f, Histological scores of ankle sections of A20myel-KONlrp3+/+ (n=5) and A20myel-KONlrp3−/− (n=5) mice. g, micro-CT images of hind paws of A20myel-KONlrp3+/+ and A20myel-KONlrp3−/− mice. Solid arrow, bone erosion; empty arrow, intact cartilage and bone. h, IL-1β serum levels of A20fl/flCasp1/11+/+ (n=11), A20myel-KOCasp1/11+/+ (n=26) and A20myel-KOCasp1/11−/− (n=16) mice aged 20-35 weeks. i, Hind paws of 25 weeks old mice. j, k, 15-30 weeks old A20myel-KOCasp1/11+/+ (n=12), A20myel-KOCasp1/11+/−(n=15) and A20myel-KOCasp1/11−/− (n=24) mice were clinically scored for arthritis incidence (j) and severity (k). l, Representative ankle joints sections; magnification: 40× (top) and 100x (bottom). P-values were determined by Student’s t-test (a, d, f, k) and Mann-Whitney test (h).