Table 1.
Patient Characteristics by sHER2 group at baseline.
| Characteristic | sHER2 <15 N=2029 (88) No. Patient (%) |
Chi-square p-value |
sHER2 ≥15 N=289 (12) No. Patient (%) |
Cohort Patients N=2318 (74) No. Patient (%) |
Chi-square p-value |
Non-Cohort Patients N=815 (26) No. Patient (%) |
|---|---|---|---|---|---|---|
|
| ||||||
| Age (median) | 49 (19–82) | 53 (23–80) | 49 (19–82) | 50 (22–79) | ||
|
| ||||||
| Age Group: | ||||||
| <40 | 373 (18) | <0.0001* | 26 (9) | 399 (17) | 0.15* | 145 (18) |
| 40–49 | 691 (34) | 85 (29) | 776 (33) | 261 (32) | ||
| 50–59 | 669 (33) | 113 (39) | 782 (34) | 238 (29) | ||
| ≥ 60 | 296 (15) | 65 (22) | 361 (16) | 171 (21) | ||
|
| ||||||
| Race: | ||||||
| White | 1723 (85) | 0.08 | 234 (81) | 1957 (84) | 0.05 | 664 (81) |
| Other | 306 (15) | 55 (19) | 361 (16) | 151 (19) | ||
|
| ||||||
| Menopausal Status: | ||||||
| Pre-menopausal or < 50 | 1147 (57) | <0.0001 | 107 (37) | 1254 (54) | 0.59 | 432 (53) |
| Post-menopausal or ≥ 50 | 882 (43) | 182 (63) | 1064 (46) | 383 (47) | ||
|
| ||||||
| ER/PR Status: | ||||||
| ER or PR Positive | 1112 (55) | 0.01 | 135 (47) | 1247 (54) | 0.78 | 443 (54) |
| Other | 917 (45) | 154 (53) | 1071 (46) | 372 (46) | ||
|
| ||||||
| Surgery: | ||||||
| Breast Conserving | 796 (39) | 0.77 | 116 (40) | 912 (39) | 0.18 | 299 (37) |
| Mastectomy | 1233 (61) | 173 (60) | 1406 (61) | 516 (63) | ||
|
| ||||||
| Nodal Status: | ||||||
| Positive | 1751 (86) | 0.09 | 260 (90) | 2011 (87) | 0.93 | 706 (87) |
| Negative | 278 (14) | 29 (10) | 307 (13) | 109 (13) | ||
|
| ||||||
| Predominant Histology: | ||||||
| Ductal | 1922 (95) | 0.98± | 274 (95) | 2196 (95) | 0.51± | 767 (94) |
| Lobular | 59 (3) | 8 (3) | 67 (3) | 30 (4) | ||
| Other | 46 (2) | 7 (2) | 53 (2) | 17 (2) | ||
| Missing | 2 (0.1) | 0 (0) | 2 (0.1) | 1 (0.2) | ||
|
| ||||||
| Histologic Tumor Grade (Elston/SBR): | ||||||
| Well/Intermediate | 589 (29) | 0.12 | 71 (25) | 660 (28) | 0.84 | 235 (29) |
| Poor | 1440 (71) | 218 (75) | 1658 (72) | 580 (71) | ||
|
| ||||||
| Pathologic Tumor Size: | ||||||
| < 2 cm | 705 (35) | 0.07 | 85 (29) | 790 (34) | 0.02 | 242 (30) |
| ≥ 2 cm | 1324 (65) | 204 (71) | 1528 (66) | 573 (70) | ||
|
| ||||||
| Hormonal Treatment: | ||||||
| Yes | 1088 (54) | 0.0002 | 122 (42) | 1210 (52) | 0.77± | 418 (51) |
| No | 930 (46) | 166 (57) | 1096 (47) | 388 (48) | ||
| Missing | 11 (0.5) | 1 (0.3) | 12 (0.5) | 9 (1) | ||
*
Mantel-Haenszel trend test,
±
Missing not included in comparison