Table 2.

Comparison of the prevalence of component features of the VATER/VACTERL association between first-degree relatives of affected patients and the general population (EUROCAT 1980–2009)

	Odds ratio	95 % confidence interval	p value
Vertebral anomalies	–	–	–
Anal atresia/stenosis	–	–	–
Cardiac anomalies	1.31	0.33–5.26	0.70
Tracheoesophageal anomalies	17.65	2.47–126.05	0.0042‡
Renal anomalies	–	–	–
Limb anomalies	4.58	0.64–32.58	0.13

^†The control cohort comprised 1.4 million infants born between 1980 and 2009 who were assessed for the European Surveillance of Congenital Anomalies (EUROCAT) registry

^‡Statistically significant results are given in bold