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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2014 Jun 4;13(8):2050–2061. doi: 10.1158/1535-7163.MCT-13-1063

Figure 2.

Figure 2

Identification of FAK inhibitor sensitive and resistant ovarian carcinoma cells. A, the indicated ovarian carcinoma cell lines were evaluated for anchorage-independent growth over 72 h in DMSO (control) or increasing concentrations of VS-4718 (0.1 to 1.0 μM). Values are means (+/− SEM) of triplicate points from three independent experiments (*** p<0.001 versus control). B, lysates of the indicated cells cultured in suspension with DMSO or VS-4718 (1 μM) for 72 h were analyzed by immunoblotting for pY397 FAK, pS473 AKT, and β5 integrin levels. Corresponding levels of total FAK, Akt, and GAPDH are shown. BT474 breast carcinoma cells are a positive control for pS473 AKT.