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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nat Med. 2014 Jul 6;20(8):942–947. doi: 10.1038/nm.3614

Figure 3. Anti-inflammatory effects of Gpr120 agonism.

Figure 3

(a) Effect of Gpr120 agonist on 3T3-L1 adipocyte CM-induced chemotaxis of primary macrophage from WT and Gpr120 KO mice. (b) In vivo tracking of PKH26 positive monocytes in WT and Gpr120 KO mice on HFD or HFD+ω3-FA (W3) or HFD+cpdA. n=6 per group. (c) ATM content by F4/80 staining in adipose tissue sections from WT and Gpr120 KO mice on HFD or HFD+cpdA. Scale bar indicates 250 μm. (d) FACS analysis of ATMs from WT and Gpr120 KO mice on HFD or HFD+cpdA. n=6 per group. (e) Relative mRNA level of inflammatory cytokines (upper row) and anti-inflammatory cytokines (lower row) in adipose tissue from WT and Gpr120 KO mice from HFD or HFD+cpdA. n= 10 per group. (f) Serum Il–6, Mcp–1, Kc, and Pai–1 levels from WT and Gpr120 KO mice on HFD or HFD+cpdA. n= 10 per group. Data are expressed as the mean±SEM. *, P<0.05 versus WT mice on HFD.