Table 3.
Effect of losartan and chelerythrine on cardiac function in Langendorff-perfused rat hearts.
| Pre-ischemia | ||||||
|---|---|---|---|---|---|---|
| Parameters | APC | IPC/APC | APC+ L | IPC/APC+ L | APC+C | IPC/APC+ C |
| HR, beats/min | 318±8 | 265±12* | 302±12 | 284±8 | 305±16 | 252±6┴ |
| LVDP, mmHg | 57±3 | 43±2* | 35±3* | 34±1& | 46±4* | 45±2 |
| +dP/dt, mmHg/sec | 1381±62 | 1018±40* | 903±67* | 789±16& | 1140±84* | 969±22 |
| RPP, beats × mmHg × min-1 | 18126±963 | 11395±699* | 10570±817* | 9656±320 | 14030±925* | 11340±403 |
| Post-ischemia | ||||||
| HR, beats/min | 296±15 | 297±12 | 288±9 | 310±7 | 325±14 | 266±13 |
| LVDP, mmHg % of Pre-ischemia |
15±1 29±4 |
22±2* 51±3* |
9±1* 26±3 |
14±1& 43±4 |
14±3 30±4 |
21±2 48±3┴ |
| +dP/dt, mmHg/sec % of Pre-ischemia |
295±23 23±2 |
591±40* 59±3 |
187±48* 20±4 |
383±36& 49±5 |
352±73 29±5 |
554±55 58±5┴ |
| RPP, beats × mmHg × min-1 % of Pre-ischemia |
4440±421 25±3 |
6534±576* 57±2* |
2592±442* 24±3 |
4340±421& 45±4& |
4550±768 32±5 |
5586±375 49±2┴ |
See Materials and Methods for details. Pre-ischemia values were determined 5 min before global ischemia whereas post-ischemia values were taken at 60 min of reperfusion. The values shown are the means ± SEM of 9-12 experiments per group. L= losartan and C = chelerythrine.
*
P<0.05 vs APC,
&
P<0.05 vs IPC/APC and
┴
P<0.05 vs APC+C.