Figure 8. Imaging with in vivo bioluminescence probes reveal tissue-specific activation of candidate genes following status epilepticus.

(A) Representative time course of an in vivo bioluminescence experiment of promoter activation after brain insults. Initially, the virus harboring the promoter-bioluminescence reporter construct is injected in relevant brain structures such as the hippocampus. Days later, the first in vivo bioluminescence analysis (IVIS) is performed. The insult, e.g. status epilepticus is induced. Repetitive IVIS analyses are following before the animal is sacrificed for histology. (B) Representative increased in vivo bioluminescence reflects increased candidate promoter activity after SE.