Thermogenic effects of MTII treatment in diet-induced obese C57BL/6J mice housed at thermoneutrality or room temperature. (A) Tb, TEE, RER, and activity in DIO mice (mean body weight, 45.6 g) treated with MTII (black circles) or vehicle (white circles) in a randomized cross-over design studied at 30 °C (n=6/group). (B) Tb, TEE, RER, and activity in the same mice studied at 22 °C (n=9/group). Data are mean ±SEM.