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. 1995 Aug 15;92(17):7976–7980. doi: 10.1073/pnas.92.17.7976

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

P G Coulie 1, F Lehmann 1, B Lethé 1, J Herman 1, C Lurquin 1, M Andrawiss 1, T Boon 1
PMCID: PMC41269  PMID: 7644523

Abstract

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions.

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Selected References

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