Table 2.
Reported cases of intraoral basal cell carcinoma
| Reference | Age | Sex Race |
Site | Clinical Presentation |
Immunohistochemical Staining | Comments | Our interpretation |
|---|---|---|---|---|---|---|---|
| Saint [4] | n/a | n/a | Mid-dorsum of tongue and soft palate | Diffuse, flat, non-ulcerated growth with deep invasion | None | Called a “basal-celled carcinoma” | May represent a basaloid SCC |
| Thoma [30] | 62 | M, C | R anterior mandible | Soft swelling, involving #27–29 | None | History of epidermoid carcinoma in floor of mouth | May represent a basaloid SCCA |
| Keen [32] | 66 | M, C | Inner mucosal surface of lower lip | Firm, white, indurated lesion, involving buccal gingiva of #23–26 | None | Patient had prior history of BCCA (cheek, neck, upper lip) | Cutaneous BCC |
| Lawson et al. [24] | 60 | M, C | Maxillary L buccal gingiva, around #10 & 11 | Red, pebbly, rough, ovoid lesion with irregular borders | None | Recurrence in 6 mos.; Previous BCCA lesion of nose removed 6 years Prior | Inadequate documentation |
| Williamson et al. [31] | 74 | M, C | Mandibular gingiva | Slightly raised, ovoid, sessile swelling of mandibular buccal gingiva of #22–25 | None | Previous history of BCCA (eyelids, temple) | Ameloblastic Carcinoma |
| Mori et al. [25] |
41 66 |
F M |
L mandibular ridge L mandibular gingiva |
Large swelling in molar region Painless swelling in #17 area for 15 years duration, now involving posterior alveolar bone of maxilla |
None | None available | Inadequate documentation |
| Liroff [27] | 47 | M, C | L maxilla, lingual and posterior to #15 | Red, round ulceration with raised, rolled borders | None | Previous history of BCCA of eyelid and psoriasis | May represent a PA |
| Peters, et al. [26] |
72 55 |
F F, C |
R posterior maxilla L posterior maxilla |
Red, tender ulceration large red ulcer of attached gingiva involving teeth #14 & 15 | None | No recurrence recurrence 5 years later | Inadequate documentation |
| Simpson, et al. [29] | 28 | M, C | L mandibular ridge | Nodular mass, distal to #18 | None | May represent a PA | |
| Samit [28] | 44 | M, C | L anterior tonsillar pillar, extending into soft palate and retromolar pad | Ulceration and soreness | None | Recurrence 7.5 years later, as a painful ulcerated, nodular buccal mass; red, cratered depression in lingual cortex of body and ramus | May represent a basaloid SCC |
| Edmonson et al. [34] | 49 | M | L retromolar pad | Ulcer under denture | None | Recurrence 3 years later | Ameloblastic Carcinoma or IOBCC |
| Blinder et al. [33] | 78 | F | R mandibular ridge | Diffuse ulceration | None | Recurrence 2 years later; history of BCCA on shoulder | Metastatic lesion in patient with known cutaneous BCC |
| Del Rosario et al. [5] | 69 | M | R buccal mucosa | Ulcerated plaque | Ber-EP4+ | Previous “cancer” in site 10 years prior | IOBCC |
| Koutlas et al. [22] | 67 | F | L buccal gingiva distal to #18- premolar region; oropharynx | Unknown | Ber-EP4 + calretinin, vimentin, actin, desmin, S100 (only few cells positive) | Recurrence 8 times in 20 years | IOBCC |
| Shumway et al. [6] | 73 | F | L anterior buccal mucosa | Non-tender mass | Ber-EP4 and p63 positive, calretinin (weak) cytokeratin focal & mildly positive | IOBCC | |
| Our cases |
39 75 74 |
F M F |
Hard palatal mucosa R Retromolar pad R posterior buccal mucosa |
Erythematous growth Ulcerated swelling Erythroleukoplakia |
Ber-EP4 positive, EMA and calretinin negative for all 3 cases | Case 1 had post-surgical neuralgia |
IOBCC IOBCC IOBCC |
C caucasian, M male, F female, R right, L left, PA peripheral ameloblastoma, BCCA basal cell carcinoma, EMA epithelial membrane antigen, n/a not available