Table 2.
Respiratory symptoms during follow-up in children with recurrent wheezing or asthma and healthy children a
|
Clinical characteristics |
Wheezing/asthma (n = 329) |
Healthy children (n = 364) |
p-value |
||
|---|---|---|---|---|---|
| N | % | N | % | ||
|
Days with fever (≥37°), mean ± SD |
7.3 ± 7.3 |
5.9 ± 6.4 |
0.009 |
||
| 0 |
66 |
20.1 |
92 |
25.3 |
|
| 1-4 |
87 |
26.4 |
99 |
27.2 |
|
| 5-9 |
74 |
22.5 |
101 |
27.7 |
|
| ≥10 |
102 |
31.0 |
72 |
19.8 |
0.005 |
|
Days with cough, mean ± SD |
31.7 ± 29.9 |
17.9 ± 23.7 |
<0.001 |
||
| 0 |
20 |
6.1 |
81 |
22.2 |
|
| 1-6 |
33 |
10.0 |
68 |
18.7 |
|
| 7-20 |
107 |
32.5 |
108 |
29.7 |
|
| ≥21 |
169 |
51.4 |
107 |
29.4 |
<0.001 |
|
Rhinitis |
|
|
|
|
|
| 0 |
270 |
82.1 |
321 |
88.2 |
|
| 1 |
38 |
11.5 |
23 |
6.3 |
|
| ≥2 |
21 |
6.4 |
20 |
5.5 |
0.04 |
|
Rhinosinusitis |
|
|
|
|
|
| 0 |
315 |
95.7 |
351 |
96.4 |
|
| ≥1 |
14 |
4.3 |
13 |
3.6 |
0.64 |
|
Pharyngitis |
|
|
|
|
|
| 0 |
239 |
72.6 |
274 |
75.3 |
|
| 1 |
52 |
15.8 |
56 |
15.4 |
|
| ≥2 |
38 |
11.6 |
34 |
9.3 |
0.61 |
|
Acute otitis media |
|
|
|
|
|
| 0 |
263 |
79.9 |
313 |
86.0 |
|
| 1 |
40 |
12.2 |
28 |
7.7 |
|
| ≥2 |
26 |
7.9 |
23 |
6.3 |
0.09 |
|
Laryngitis |
|
|
|
|
|
| 0 |
304 |
92.4 |
338 |
92.9 |
|
| ≥1 |
25 |
7.6 |
26 |
7.1 |
0.82 |
|
Tracheitis |
|
|
|
|
|
| 0 |
294 |
89.4 |
344 |
94.5 |
|
| ≥1 |
35 |
10.6 |
20 |
5.5 |
0.01 |
|
Asthmatic attacks |
|
|
|
|
|
| 0 |
170 |
51.7 |
335 |
92.0 |
|
| 1 |
63 |
19.1 |
19 |
5.2 |
|
| 2 |
46 |
14.0 |
4 |
1.1 |
|
| ≥3 |
50 |
15.2 |
6 |
1.7 |
<0.001 |
|
Pneumonia |
|
|
|
|
|
| 0 |
221 |
67.2 |
309 |
84.9 |
|
| 1 |
61 |
18.5 |
31 |
8.5 |
|
| ≥2 |
47 |
14.3 |
24 |
6.6 |
<0.001 |
|
Hospitalizations |
|
|
|
|
|
| No |
306 |
93.0 |
353 |
97.0 |
|
| Yes |
23 |
7.0 |
11 |
3.0 |
0.02 |
|
Subjects with a complete follow-up
a
|
306 |
93.0 |
346 |
95.0 |
0.25 |
| Months of follow-up, mean ± SD a | 11.9 ± 0.6 | 11.9 ± 0.5 | 0.26 | ||
aAnalyses were based on subjects with available information for at least 9 months of follow-up. SD: standard deviation; p-values were calculated using the χ2 test or Wilcoxon’s rank-sum test, as appropriate. Parental-eport of physician-diagnosed episodes.