Table 2.

Multivariable models for longitudinal viral load (VL) at two overlapping intervals of early HIV-1 infection

Factors in model	Analyses of VLa in the 2–36 months interval				Analyses of VLa in the 3–24 months intervalb
	n	Δβ	SE	Adjusted P	n	Δβ	SE	Adjusted P
Age (if >40)c	80	−0.06	0.10	0.536	75	−0.10	0.10	0.309
Region (if Zambia)	206	0.36	0.07	<0.0001	199	0.38	0.07	<0.0001
DOI (every 3 months)	521	−0.02	0.01	<0.0001	503	−0.02	0.01	0.007
HLA-B*18	34	0.34	0.14	0.015	34	0.33	0.14	0.023
HLA-B*45	83	0.25	0.09	0.009	82	0.22	0.10	0.027
HLA-B*53	101	0.22	0.09	0.013	93	0.19	0.09	0.047
HLA-B*57	48	−0.48	0.12	<0.0001	46	−0.48	0.12	0.0001
Female sex	194	−0.27	0.07	<0.001	187	−0.29	0.08	<0.001
Female sex × HLA-A*03	22	−0.67	0.24	0.005	22	−0.71	0.25	0.005

^aRepeated measurements, with log₁₀-transformation before analysis. Summary statistics: Δβ regression beta (mean deviation, Δ, from the reference group), SE standard error of the mean Δβ

^bAs part of the sensitivity analyses (see text)

^cFor consistency with earlier work, age is retained as a covariate regardless of its statistical significance