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. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: Pediatr Blood Cancer. 2012 Dec 19;60(6):994–1000. doi: 10.1002/pbc.24419

Table I.

Current COG Risk Stratification for Pediatric Renal Tumors

Patient Age Tumor
Weight
Stage,
Histology
LOH at both
1p and 16q
Rapid Lung
Nodule
Response
Risk Group Treatment
Study
< 2 yrs < 550 g I, FH Any N/A Very Low AREN0532
< 2 yrs ≥550 g I, FH None N/A Low None
≥2yrs Any I, FH None N/A Low None
Any Any II, FH None N/A Low None
≥ 2yrs Any I, FH LOH N/A Standard AREN0532
Any ≥550 g I, FH LOH N/A Standard AREN0532
Any Any II, FH LOH N/A Standard AREN0532
Any Any III, FH None Any Standard AREN0532
Any Any III, FH LOH Any Higher-FH AREN0533
Any Any IV, FH LOH Any Higher-FH AREN0533
Any Any IV, FH None Yes Standard AREN0533
Any Any IV, FH None No Higher-FH AREN0533
Any Any V, FH, AH Any Any Bilateral AREN0534
Any Any I-IV, AH, CCSK, RCC, MRT Any Any High AREN0321

FH-Favorable histology Wilms tumor; AH-Anaplastic histology Wilms tumor; CCSK-Clear cell sarcoma of the kidney; RCC- renal cell carcinoma; MRT- malignant rhabdoid tumor