Table I.
Current COG Risk Stratification for Pediatric Renal Tumors
| Patient Age | Tumor Weight |
Stage, Histology |
LOH at both 1p and 16q |
Rapid Lung Nodule Response |
Risk Group | Treatment Study |
|---|---|---|---|---|---|---|
| < 2 yrs | < 550 g | I, FH | Any | N/A | Very Low | AREN0532 |
| < 2 yrs | ≥550 g | I, FH | None | N/A | Low | None |
| ≥2yrs | Any | I, FH | None | N/A | Low | None |
| Any | Any | II, FH | None | N/A | Low | None |
| ≥ 2yrs | Any | I, FH | LOH | N/A | Standard | AREN0532 |
| Any | ≥550 g | I, FH | LOH | N/A | Standard | AREN0532 |
| Any | Any | II, FH | LOH | N/A | Standard | AREN0532 |
| Any | Any | III, FH | None | Any | Standard | AREN0532 |
| Any | Any | III, FH | LOH | Any | Higher-FH | AREN0533 |
| Any | Any | IV, FH | LOH | Any | Higher-FH | AREN0533 |
| Any | Any | IV, FH | None | Yes | Standard | AREN0533 |
| Any | Any | IV, FH | None | No | Higher-FH | AREN0533 |
| Any | Any | V, FH, AH | Any | Any | Bilateral | AREN0534 |
| Any | Any | I-IV, AH, CCSK, RCC, MRT | Any | Any | High | AREN0321 |
FH-Favorable histology Wilms tumor; AH-Anaplastic histology Wilms tumor; CCSK-Clear cell sarcoma of the kidney; RCC- renal cell carcinoma; MRT- malignant rhabdoid tumor