Skip to main content
. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: J Neurosci Res. 2008 Nov 1;86(14):3096–3105. doi: 10.1002/jnr.21765

Figure 1.

Figure 1

Opposing effects of different concentrations of extracellular ATP on DNA synthesis induced by FGF2. Quiescent cultures of rat cortical astrocytes were treated with FGF2 (25 ng/ml) or in combination with different concentrations of ATP (30–1000 uM), and DNA synthesis was measured as described in Materials and Methods. H3-Thymidine incorporation in control cultures was 16,609 ± 995 cpm/mg protein (Mean ± SEM, n = 4). FGF2-induced DNA synthesis was significantly enhanced by 30 uM and 100 uM ATP whereas this effect was significantly inhibited by 300 uM and 1000 uM ATP (* p<0.05; ** p<0.01; *** p<0.001).