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. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: J Neurosci Res. 2008 Nov 1;86(14):3096–3105. doi: 10.1002/jnr.21765

Figure 7.

Figure 7

Activation of P2X7 receptors overcomes the potentiating effect of P2Y purine/pyrimidine receptors on FGF2-induced DNA synthesis. Quiescent cultures of rat cortical astrocytes were treated with FGF2 (25 ng/ml), in combination with UTP (100 uM) or BzATP (100 uM), or with all three agents, and DNA synthesis was measured as described in Materials and Methods. Thymidine incorporation in FGF2-treated cultures was increased 411 ± 54 % (Mean ± SEM, n = 7) compared to control cultures. Data from cultures treated with FGF2 and UTP and/or BzATP are expressed as %FGF2. DNA synthesis induced by FGF2 and UTP was significantly decreased by the addition of BzATP (* p<0.001).