Figure 6.

The response of HE(8) and HE(12) motor neurons receiving dynamic clamp-mediated synchronous synaptic conductance waveforms extracted from ensemble model simulations. A, Intracellular recordings and synaptic conductances (g_Syn) of the HE(8) and HE(12) motor neurons receiving the synchronous 5/19A temporal and synaptic strength profiles (A₁), 5/27B temporal pattern and synaptic strength profiles (A₂), the 5/27B temporal pattern matched with the 5/22B synaptic strength profiles (A₃), and the inverted 5/27B synaptic strength profiles (A₄) are shown. An iconic representation of the temporal pattern (left panel) and the synaptic strength profiles (right panel) are shown to the right of the voltage trace (color code: Fig. 1). The vertical dashed lines are aligned to the HN(4) interneuron middle spike phase, facilitating a comparison of the temporal patterns of the premotor interneurons measured in these preparations. The large circles represent cell bodies of the HE(8) and HE(12) motor neurons. The sizes of the filled circles show the relative synaptic strengths of the premotor HN interneurons onto the heart motor neurons measured in the living system on those days. B, Average (±SD; n = 6) synchronous motor phase progression of the heart motor neurons from experiments described in A. The brackets represent the statistical comparison of the 5/27B temporal pattern matched with the 5/27B inverted synaptic strength profiles to the other input waveforms. The asterisk and brackets indicate a significant difference in motor phase progression between the 5/27B temporal pattern matched with the conductance waveform of the 5/27B inverted synaptic strength profiles and the other input patterns (one-way repeated-measures ANOVA, p < 0.05).