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. Author manuscript; available in PMC: 2014 Aug 9.
Published in final edited form as: Nature. 2013 Dec 25;506(7486):97–101. doi: 10.1038/nature12828

Extended Data Figure 3. Conditional analyses reveal multiple independent signals at INS-IGF2 and KCNQ1.

Extended Data Figure 3

Regional plots are shown for the interval spanning INS-IGF2 and KCNQ1 (a) without conditioning, (b) conditional on rs2237897 at KCNQ1, (c) conditional on rs2237897 and rs139647931 (both at KCNQ1), and (d) conditional on rs2237897 and rs139647931 (both at KCNQ1) and rs11564732 (the top associated variant in the INS-IGF2-TH region). The top SNPs in 11p15.5 and KCNQ1 are ~700 kb away from each other, but despite this proximity, there is a strong residual signal of association at INS-IGF2 after analysis conditional on genotype at KCNQ1. Point color indicates r2 to rs11564732 and recombination rate is also shown, both based on the 1,000 Genomes ASN population.