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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Thromb Haemost. 2014 Jun 27;12(8):1331–1341. doi: 10.1111/jth.12619

Figure 5. CAN12 inhibits aggregation through PAR4.

Figure 5

Washed platelets were isolated from wild-type and PAR4−/− mice. Following treatment with goat IgG (2.0 μg/ml) or CAN12(2.0 μg/ml) for 10 min at 37°C percent aggregation was evaluated for (A) wild-type and (B) PAR4−/− platelets activated with AYPGFK (500 μM), ADP (5 μM) supplemented with 1 mg/ml fibrinogen, or collagen (1 μg/ml). **p<0.01 vs. IgG