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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Thromb Haemost. 2014 Jun 27;12(8):1331–1341. doi: 10.1111/jth.12619

Figure 6. CAN12 inhibits arterial thrombosis.

Figure 6

(A) C57BL/6 mice were pretreated with saline, goat IgG (2 mg/kg), or CAN12 (1, 0.5, 0.25, 0.125 mg/kg) for 10 min and then subjected to the Rose Bengal carotid artery thrombosis model. Time to complete occlusion is indicated or the experiment was terminated at 90 min. (B) The concentration of platelets in the blood at termination of the experiment was determined. (C) 15 minutes after the initiation of carotid artery thrombosis, C57BL/6 mice were injected with goat IgG (2 mg/kg) or CAN12 (0.5 mg/kg) and the time to complete arterial occlusion was determined. The experiment was terminated at 90 min. (D) The concentration of platelets in the blood at termination of the experiment was determined. **p<0.01