Table 3b.

VOCs in IBD: After adjusting for age, gender, race and BMI, results showed significant differences in 6 of the 9 VOCs including 1-decene, 1-nonene, 1-octene, 3- methylhexane, (E)-2-nonene and hydrogen sulfide. The adjusted data was calculated using a regression model (ANCOVA analysis), but given asymmetrical distribution of values, a log transformation was performed for each VOC and presented as Mean (95% CI).

Factor (ppb)	Control (N=55)	IBD (N=62)	p-value
2-propanol	90.4 (78.9, 103.7)	105.4 (90.2, 123.2)	0.19
acetaldehyde	29.2 (24.6, 34.5)	32.6 (26.9, 39.5)	0.44
acetone	50.0 (38.8, 64.4)	51.2 (38.3, 68.2)	0.92
acrylonitrile	0.58 (0.53, 0.64)	0.56 (0.51, 0.63)	0.78
benzene	1.8 (1.6, 2.1)	2.1 (1.8, 2.4)	0.26
carbon disulfide	1.7 (1.5, 2.0)	1.6 (1.4, 1.9)	0.72
dimethyl sulfide	1.3 (1.1, 1.4)	1.2 (1.03, 1.4)	0.6
ethanol	172.9 (127.8, 233.8)	253.9 (180.0, 358.1)	0.14
isoprene	5.9 (4.8, 7.2)	7.8 (6.1, 9.8)	0.11
pentane	11.6 (10.1, 13.3)	14.1 (12.0, 16.6)	0.1
1-decene	2.1 (1.7, 2.6)	8.3 (6.5, 10.7)	<0.001
1-heptene	6.4 (5.3, 7.9)	8.5 (6.7, 10.7)	0.11
1-nonene	8.3 (6.6, 10.4)	3.8 (2.9, 4.9)	<0.001
1-octene	4.4 (3.7, 5.3)	18.4 (14.9, 22.6)	<0.001
3-methylhexane	14.3 (11.6, 17.7)	23.6 (18.6, 30.0)	0.006
(E)-2-nonene	11.7 (9.3, 14.8)	1.5 (1.2, 2.0)	<0.001
ammonia	48.4 (42.8, 54.9)	47.7 (41.3, 54.9)	0.88
ethane	63.6 (61.2, 66.1)	63.1 (60.4, 66.0)	0.81
hydrogen sulfide	0.36 (0.33, 0.40)	0.28 (0.25, 0.32)	0.003
triethyl amine	0.66 (0.58, 0.76)	0.63 (0.54, 0.73)	0.66
trimethyl amine	3.4 (2.9, 4.0)	4.1 (3.4, 4.9)	0.19

Values presented as Mean (95% CL) and were obtained using ANCOVA analysis. The logarithm of each VOC was modeled as the outcome variable with age, gender, Caucasian race and BMI percentile as the independent variables.