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Vein wall MMP-9 (A) and -2 (B, all n=8-12, ***p<0.001, ****p<0.0001) activity is diminished during thrombus resolution (6d and 14d) in Vn−/− and PAI-1 Tg mice compared to WT controls. TIMP-1 levels were similarly decreased in PAI-1 Tg mice and Vn−/− vein wall (C, n=5-10 *p<0.05, **p<0.01).
