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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Microbiol. 2014 Jul 16;93(4):682–697. doi: 10.1111/mmi.12681

Figure 4.

Figure 4

A mutation in the DNA binding domain of CarD affects the pathogenesis of M. tuberculosis in murine tissues. C57BL/6 mice were infected by the aerosol route with the M. tuberculosis strains expressing either CarDWT (black circles) or CarDK125A (grey squares). Shown are bacterial titers in the lungs (A) and spleens (B) of the infected mice. Each time point is the mean ± SEM of data from 6 mice per strain, combined from two experiments. The significance of the differences between the CarDK125A and the CarDWT strain in both panels were determined as described for Figure 2.