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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Microbiol. 2014 Jul 16;93(4):682–697. doi: 10.1111/mmi.12681

Figure 8.

Figure 8

Model of CarD activity at promoters. CarD is targeted to the initiation complex via its interaction with RNAP-β (1). The C-terminus of CarD then interacts with the DNA (2). The combined association of CarD with the RNAP and CarD with the promoter DNA stabilizes the RNAP-promoter complex. Within the CarD-RNAP-promoter complex, the conserved tryptophan in CarD performs a function to facilitate CarD activity (3). The efficient functioning of all three of CarD’s activities improves viability and resistance to stress and results in changes in gene expression (4).