Table 1.
CarD mutants studied in this paper
Mutation in CarD | M. smegmatis | M. tuberculosis | Activity Affected by Mutation |
---|---|---|---|
R25E | Viable | Unattainable | Interaction with RNAP |
R47E | Viable | Viable | Interaction with RNAP |
W85A | Viable | Unattainable | Unknown |
K90A | Viable | Unattainable | Interaction with dsDNA |
K90E | Viable | Unattainable | Interaction with dsDNA |
K125A | Viable | Viable | None Determined |
K125E | Viable | Unattainable | Interaction with dsDNA |