Table 1.
Effects of ruscogenin on body weight, liver and visceral fat weight, and feeding behaviors of hamsters.
| RCD-fed | HFD-fed | ||||
|---|---|---|---|---|---|
| Vehicle | Vehicle | Ruscogenin (mg/kg/day) | |||
| 0.3 | 1.0 | 3.0 | |||
| Final body weight (BW) (g) | 127.1 ± 9.1d | 164.3 ± 7.1b | 158.4 ± 8.1b | 153.9 ± 6.3b | 147.3 ± 7.3a,c |
| Epididymal WAT (g/100 g BW) | 1.6 ± 0.3d | 2.5 ± 0.3b | 2.1 ± 0.4b | 1.9 ± 0.2d | 1.8 ± 0.3d |
| Perirenal WAT (g/100 g BW) | 0.8 ± 0.2c | 1.2 ± 0.2a | 1.1 ± 0.3 | 1.1 ± 0.2 | 0.9 ± 0.2 |
| Liver weight (g/100 g BW) | 4.8 ± 0.3c | 5.7 ± 0.3a | 5.5 ± 0.3a | 5.2 ± 0.3 | 5.1 ± 0.3 |
| Food intake (g/day) | 9.9 ± 1.3 | 11.0 ± 1.3 | 10.7 ± 1.8 | 10.9 ± 1.4 | 9.8 ± 1.5 |
| Water intake (mL/day) | 12.6 ± 4.4 | 13.2 ± 6.2 | 13.0 ± 4.5 | 12.6 ± 5.9 | 13.1 ± 4.3 |
The vehicle (distilled water) used to prepare the tested medication solution was given at the same volume. Values (mean ± SEM) were obtained from each group of 8 animals after 8 weeks of the experimental period. a P < 0.05 and b P < 0.01 compared to the values of vehicle-treated RCD-fed hamsters in each group, respectively. c P < 0.05 and d P < 0.01 compared to the values of vehicle-treated HFD-fed hamsters in each group, respectively.