Table 4.
Adverse effects associated with preoperative and postoperative chemotherapy.
| Adverse events | Neoadjuvant group (n = 23) |
Adjuvant group (n = 35) |
P value∗ |
|---|---|---|---|
| Neutropenia: n (%) | |||
| Grades 1-2 | 6 (26.1) | 7 (20.0) | NS |
| Grades 3-4 | 3 (13.0) | 3 (8.8) | |
| Nausea and vomiting: n (%) | |||
| Grades 1-2 | 4 (17.4) | 8 (22.9) | NS |
| Grades 3-4 | 1 (4.3) | 2 (5.7) | |
| Liver toxicity: n (%) | |||
| Grades 1-2 | 1 (4.3) | 2 (5.7) | NS |
| Grades 3-4 | 0 (0) | 0 (0) | |
| Stomatitis: n (%) | |||
| Grades 1-2 | 2 (8.7) | 1 (2.9) | NS |
| Grades 3-4 | 0 (0) | 0 (0) | |
| Diarrhea: n (%) | |||
| Grades 1-2 | 2 (8.7) | 2 (5.7) | NS |
| Grades 3-4 | 0 (0) | 2 (5.7) | |
| Neurologic effects: n (%) | |||
| Grades 1-2 | 4 (17.4) | 2 (5.7) | NS |
| Grades 3-4 | 0 (0) | 0 (0) | |
| Skin effects: n (%) | |||
| Grades 1-2 | 1 (4.3) | 1 (2.9) | NS |
| Grades 3-4 | 0 (0) | 0 (0) |
*Comparisons for categorical variables performed using chi-square test. NS: no significance.