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Toxic metals induce HSP70i accumulation in podocytes in a dose-dependent manner. Results of a quantitative western blot analysis of HSP70i accumulation in podocytes treated with various concentrations of individual toxic metals (a) or combinations of two and three toxic metals totaling 10, 20, or 40 mM (b) for 3 days. Values are expressed as ng of HSP70i per mg total protein. Basal HSP70i levels were below the limits of detection [100].
