Table 1.
Characteristics of 145 CML-CP patients by treatment arm
| IM400 (N=72) | IM800 (N=73) | P* | |||
|---|---|---|---|---|---|
| Median | Min–Max | Median | Min–Max | ||
| Age (yrs) | 50 | 23–80 | 52 | 19–82 | 0.76 |
| WBC (109/L) | 74.8 | 5.3–393 | 64.7 | 1.1–474 | 0.57 |
| Basophils (%) [N=143] | 3 | 0–17 | 2 | 0–19 | 0.12 |
| Platelets (109/L) | 398 | 128–2168 | 370 | 140–2485 | 0.57 |
| BM blasts (%) [N=142] | 2 | 0–8 | 2 | 0–8 | 0.55 |
|
| |||||
| Pts | % | Pts | % | P* | |
|
| |||||
| Sex | |||||
| Female | 27 | 38% | 26 | 36% | 0.86 |
| Male | 45 | 63% | 47 | 64% | |
|
| |||||
| Hasford Risk Category | |||||
| Low | 15 | 21% | 15 | 21% | 1.00 |
| Inter. | 22 | 31% | 22 | 30% | |
| High | 35 | 49% | 36 | 49% | |
|
| |||||
| Performance Status | |||||
| 0 | 49 | 68% | 44 | 61% | 0.48 |
| 1 | 22 | 31% | 25 | 35% | |
| 2 | 1 | 1% | 3 | 4% | |
| Unknown | 0 | --- | 1 | --- | |
|
| |||||
| Palpable Splenomegaly | |||||
| Yes | 30 | 42% | 34 | 48% | 0.50 |
| No | 42 | 58% | 37 | 52% | |
| Unknown | 0 | ---- | 2 | --- | |
|
| |||||
| Palpable Hepatomegaly | |||||
| Yes | 2 | 3% | 3 | 4% | 0.68 |
| No | 69 | 97% | 65 | 96% | |
| Unknown. | 1 | --- | 5 | -- | |
*
Two-sided p-value from Wilcoxon test (continuous variables) or Fisher’s exact test (sex, organomegaly). P-value from Pearson’s chi-square test for Hasford risk category and performance status. Unknowns were excluded from significance tests. Pts=patients.