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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Hum Genet. 2014 Jun 3;133(9):1093–1104. doi: 10.1007/s00439-014-1452-2

Table 1. Top 10 cis- and top 10 trans-mQTLs identified in 268 African Americans (AAs).

SNPs CpGs SNP-CpG linear regression analysis
SNPs Chr.a Coordinatesa Genes SNP Type CpGs Chr.a Coordinatesa Genes Allele Betab Pnominalc qd
Top 10 cis-mQTLs in AAs:
rs1800759 4 100065509 ADH4 Promoter cg12011299 4 100065546 ADH4 C 0.12 9.9E-100 6.7E-91
rs8028779 15 27034731 GABRB3 promoter cg07763397 15 27020865 GABRB3 G 0.09 4.6E-38 4.5E-30
rs2602836 4 100014805 ADH5 promoter cg12011299 4 100065546 ADH4 G 0.08 1.7E-37 6.7E-30
rs3828541 4 100042262 ADH4 Downstream cg12011299 4 100065546 ADH4 G 0.08 2.6E-34 1.8E-26
rs4486851 15 27022876 GABRB3 promoter cg07763397 15 27020865 GABRB3 A 0.07 9.5E-30 3.8E-22
rs732821 13 47472879 HTR2A promoter cg06020661 13 47472138 HTR2A A 0.08 8.7E-30 5.7E-22
rs1154415 4 99999033 ADH5 Intron cg12011299 4 100065546 ADH4 G 0.12 1.2E-26 4.3E-19
rs2851301 4 100010127 ADH5 promoter cg12011299 4 100065546 ADH4 A 0.12 1.2E-26 4.3E-19
rs13148577 4 100060836 ADH4 Intron cg12011299 4 100065546 ADH4 A 0.11 7.6E-26 2.6E-18
rs4147547 4 100127311 ADH6 Intron cg12011299 4 100065546 ADH4 A 0.11 8.0E-23 2.2E-15
Top 10 trans-mQTLs in AAs:
rs3097793 5 150617370 CCDC69 - GM2A intergenic cg14150516 2 208394784 CREB1 A 0.04 3.1E-43 6.5E-35
rs173567 5 150618829 CCDC69 - GM2A intergenic cg14150516 2 208394784 CREB1 G 0.04 3.8E-32 8.5E-25
rs628825 12 110436233 ATXN2 Intron cg10959984 12 112204380 ALDH2 G 0.00 3.2E-22 4.3E-15
rs11552148 16 48385957 LONP2 3′ UTR cg25195998 11 113345607 DRD2 G -0.01 9.9E-22 1.8E-14
rs8055764 16 48384370 LONP2 Intron cg25195998 11 113345607 DRD2 A -0.01 6.6E-21 7.1E-14
rs11866529 16 48247523 ABCC11 Intron cg25195998 11 113345607 DRD2 C -0.01 5.5E-21 1.1E-13
rs8054314 16 48394330 SIAH1 Downstream cg25195998 11 113345607 DRD2 A -0.01 7.3E-21 1.1E-13
rs8190 16 48394626 SIAH1 3′ UTR cg25195998 11 113345607 DRD2 A -0.01 7.3E-21 1.1E-13
rs153462 5 150605070 CCDC69 promoter cg14150516 2 208394784 CREB1 G 0.03 7.6E-20 5.9E-13
rs9926192 16 48306394 LONP2 Intron cg25195998 11 113345607 DRD2 A -0.01 4.2E-19 4.2E-12
a

Chromosomes and coordinates of SNPs and CpGs in GRCh37/hg19.

b

Regression coefficients by multiple linear regression analysis with adjustment for sex, age, ancestry proportion, and the status of alcohol dependence (AD).

c

Observed P values by multiple linear regression analysis with adjustment for sex, age, ancestry proportion, and the status of alcohol dependence (AD).

d

Adjusted P values by R package qvalue, controlling the False Discovery Rate (FDR) at 0.05.