Table 1.
Fat depot-specific gene expression in Sca1high ASCs
| Gene name | Protein name | Fat-depot | Fold-increase |
|---|---|---|---|
| Collagens and other structural ECMs | |||
| Col14a1 | Collagen alpha-1(XIV) chain | Vis | 3.9 |
| Eln | Elastin | SQ | 1.6 |
| Col6a1 | Collagen alpha-1(VI) chain | SQ | 3.6 |
| Col6a2 | Collagen alpha-2(VI) chain | SQ | 4.4 |
| Col6a3 | Collagen alpha-3(VI) chain | SQ | 4.3 |
| Col8a1 | Collagen alpha-1(VIII) chain | SQ | 1.9 |
| Col8a2 | Collagen alpha-2(VIII) chain | SQ | 1.8 |
| Proteoglycans | |||
| Lum | Lumican | Vis | 4.9 |
| Dcn | Decorin | Vis | 1.8 |
| Gpc3 | Glypican-3 | Vis | 2.2 |
| Gpc1 | Glypican-1 | SQ | 1.9 |
| Basement membrane and anchoring proteins | |||
| Lama5 | Laminin subunit alpha-5 | Vis | 2.5 |
| Lama1 | Laminin subunit alpha-1 | Vis | 2.9 |
| Nid2 | Nidogen-2 | Vis | 12.9 |
| Prelp | Prolargin | Vis | 2.0 |
| Fbln1 | Fibulin-1 | Vis | 1.9 |
| Fbln5 | Fibulin-5 | Vis | 2.2 |
| Tnxb | Tenascin-X | Vis | 3.3 |
| Tgfbi | Transforming growth factor-beta-induced protein ig-h3 | SQ | 1.9 |
| Comp | Cartilage oligomeric matrix protein | SQ | 38 |
| Proteinases and proteinase inhibitors | |||
| Pcsk6 | Proprotein convertase subtilisin/kexin type 6 | Vis | 3.3 |
| Timp1 | Metalloproteinase inhibitor 1 | Vis | 3.2 |
| Slpi | Antileukoproteinase | Vis | 5.9 |
| Kazald1 | Kazal-type serine protease inhibitor domain-containing protein 1 | Vis | 6.8 |
| Adamts1 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | Vis | 1.9 |
| Adamts5 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | Vis | 4.7 |
| Adamts8 | A disintegrin and metalloproteinase with thrombospondin motifs 8 | Vis | 7.6 |
| Adamts9 | A disintegrin and metalloproteinase with thrombospondin motifs 9 | Vis | 3.2 |
| Adamts15 | A disintegrin and metalloproteinase with thrombospondin motifs 15 | Vis | 2.7 |
| Mmp8 | Neutrophil collagenase | Vis | 25.6 |
| Mmp10 | Stromelysin-2 | Vis | 5.8 |
| Mmp13 | Collagenase 3 | Vis | 1.8 |
| Mmp17 | Matrix metalloproteinase-17 | Vis | 1.6 |
| Cpz | Carboxypeptidase Z | Vis | 4.2 |
| Mmp2 | 72 kDa type IV collagenase | SQ | 1.9 |
| Timp3 | Metalloproteinase inhibitor 3 | SQ | 2.0 |
| Mmp15 | Matrix metalloproteinase-15 | SQ | 2.6 |
| Mmp28 | Matrix metalloproteinase-28 | SQ | 2.1 |
| Serpine2 | Glia-derived nexin | SQ | 2.0 |
| TGF-beta-related | |||
| Ltbp1 | Latent-transforming growth factor beta-binding protein 1 | Vis | 3.2 |
| Ltbp2 | Latent-transforming growth factor beta-binding protein 2 | Vis | 4.0 |
| Bmp4 | Bone morphogenetic protein 4 | Vis | 10.2 |
| Tgfb3 | Transforming growth factor beta-3 | SQ | 1.7 |
| WNT activity | |||
| Wnt4 | Protein Wnt-4 | Vis | 6.6 |
| Sfrp1 | Secreted frizzled-related protein 1 | Vis | 2.2 |
| Wnt9a | Protein Wnt-9a | SQ | 2.2 |
| Wnt16 | Protein Wnt-16 | SQ | 15.4 |
| ECM modifier, cell adhesion, coagulation, and other functions | |||
| Npnt | Nephronectin | Vis | 4.3 |
| Vwc2 | Brorin | Vis | 5.8 |
| Vit | Vitrin | Vis | 5.9 |
| Clu | Clusterin | Vis | 5.4 |
| Efemp1 | EGF-containing fibulin-like extracellular matrix protein 1 | Vis | 4.5 |
| Mgp | Matrix Gla protein | Vis | 3.6 |
| Tinagl1 | Tubulointerstitial nephritis antigen-like | Vis | 2.3 |
| Lmcd1 | LIM and cysteine-rich domains protein 1 | Vis | 2.2 |
| F3 | Tissue factor | Vis | 1.7 |
| Crip2 | Cysteine-rich protein 2 | Vis | 1.6 |
| Rarres2 | Retinoic acid receptor responder protein 2 | Vis | 2.4 |
| Fgf10 | Fibroblast growth factor 10 | Vis | 2.6 |
| Ccbe1 | Collagen and calcium-binding EGF domain-containing protein 1 | Vis | 2.9 |
| Matn2 | Matrilin-2 | Vis | 1.6 |
| Spon2 | Spondin-2 | Vis | 3.1 |
| Spon1 | Spondin-1 | Vis | 2.9 |
| Chl1 | Neural cell adhesion molecule L1-like protein | Vis | 3.7 |
| Tnfrsf11b | Tumor necrosis factor receptor superfamily member 11B | Vis | 5.0 |
| Tgm2 | Protein-glutamine gamma-glutamyltransferase 2 | Vis | 4.7 |
| Clec3b | Tetranectin | Vis | 3.5 |
| Sparcl1 | SPARC-like protein 1 | Vis | 1.7 |
| Postn | Periostin | SQ | 3.6 |
| Lgals3 | Galectin-3 | SQ | 2.8 |
| Matn3 | Matrilin-3 | SQ | 2.9 |
| Ptprz1 | Receptor-type tyrosine-protein phosphatase zeta | SQ | 4.9 |
| Adamtsl3 | ADAMTS-like protein 3 | SQ | 3.6 |
| Ptn | Pleiotrophin | SQ | 2.8 |
| Lgals3bp | Galectin-3-binding protein | SQ | 1.8 |
| Olfml2a | Olfactomedin-like 2A | SQ | 8.9 |
| Nov | Protein NOV homolog | SQ | 8.0 |
| Thbs2 | Thrombospondin-2 | SQ | 5.1 |
| Mamdc2 | MAM domain-containing protein 2 | SQ | 4.0 |
| Cthrc1 | Collagen triple helix repeat-containing protein 1 | SQ | 2.0 |