Table 2.
BAL and serum BDG and GM levels and clinical response in the patients with proven/probable pulmonary IFI (n=34)
| aIFI | bRisk factor(s) | BAL BDG (Pg/ml | BAL GM (index) | Serum BDG (pg/ml) | Serum GM (index) | Response at 12 wks |
|---|---|---|---|---|---|---|
| alA | CGD | >500 | 1.02 | 97 | <0.5 | Success |
| alA | ID | 129 | <0.5 | NP | NP | Success |
| IA | AA, HSCT, GVHD, S | >500 | 2.3 | <31 | <0.5 | Success |
| IA | Heme, N | >500 | 5.5 | 296 | 1.8 | Unknown |
| IA | Heme, HSCT, S | >500 | 0.6 | <31 | <0.5 | Death |
| IA | AA, HSCT, GVHD | >500 | 7.33 | NP | NP | Success |
| IA | CGD, HSCT, S | 450 | 4.9 | >500 | 5.6 | Failure |
| IA | Heme, N, S | 117 | 0.7 | <31 | <0.5 | Failure |
| IA | Heme, HSCT, GVHD | 86 | 0.92 | 370 | <0.5 | Failure |
| IA | AA, N | 85 | 4.76 | 183 | 3.213 | Failure |
| IA | ID, HSCT, N | <31 | 11.4 | 92 | 1.2 | Failure |
| IA | CGD | <31 | <0.5 | 204 | NP | Failure |
| IA | AA, N | <31 | <0.5 | 39 | <0.5 | Failure |
| IA | Heme, HSCT, S | <31 | <0.5 | <31 | <0.5 | Failure |
| aIFI | CGD | <31 | 1.02 | <31 | NP | Failure |
| aIFI | ID | <31 | <0.5 | NP | NP | Success |
| IFI | Heme, HSCT, N | 215 | <0.5 | 137 | <0.5 | Success |
| IFI | Heme, HSCT, S | 149 | <0.5 | 93 | <0.5 | Failure |
| IFI | AA, N | 140 | <0.5 | 210 | <0.5 | Success |
| IFI | Heme, HSCT, N, S | 135 | <0.5 | 109 | <0.5 | Death |
| IFI | AA, HSCT, GVHD, N, S | 129 | <0.5 | 189 | <0.5 | Failure |
| IFI | Heme, HSCT, GVHD | <31 | <0.5 | >500 | <0.5 | Death |
| IFI | Heme, HIV, N, S | <31 | <0.5 | >500 | <0.5 | Death |
| IFI | CGD | <31 | NP | 139 | <0.5 | Success |
| aPaecilomyces | ID, HSCT, GVHD, N | >500 | 8.4 | 370 | 3.5 | Death |
| aMucormycosis | Heme, HSCT, GVHD, S | 168 | 0.56 | NP | <0.5 | Death |
| aMucormycosis | Heme, HSCT, GVHD | 86 | 0.92 | 370 | <0.5 | Failure |
| aMucormycosis | AA, N | <31 | <0.5 | <31 | <0.5 | Failure |
| aFusariosis | AA, N | <31 | <0.5 | 74 | <0.5 | Failure |
| aScopulariopsis | AA, N, S | <31 | <0.5 | <31 | <0.5 | Success |
| Fusariosis | Heme, HSCT, GVHD, N, S | 73 | <0.5 | <31 | <0.5 | Death |
| Mucormycosis | Heme, HSCT, N | 54 | <0.5 | NP | NP | Success |
| Paecilomyces | Heme, HSCT, GVHD, N, S | 35 | <0.5 | <31 | <0.5 | Death |
| Mucormycosis | AA, N | <31 | <0.5 | <31 | <0.5 | Death |
NP=not performed
a
Denotes proven cases; otherwise all other cases are probable IFI per 2008 EORTC/MSG definitions (IA=invasive aspergillosis; IFI=invasive fungal infection not otherwise specified; causative organism listed if known)
b
Risk factors annotated as follows: AA=aplastic anemia; CGD=chronic granulomatous disease; GVHD=graft versus host disease; Heme=hematologic malignancy; HIV=human immunodeficiency virus; HSCT=hematopoietic stem cell transplantation; ID=other immunodeficiency (e.g. GATA-2, DOCK-8); N=neutropenia; S=steroids (≥0.3 mg/kg/d prednisone equivalent)