Table 4.

Linear regression analysis of 10x mtDNA copy number increase and cognitive and physical performance and mortality. All values are age and sex adjusted.Participants from the MADT, the LSADT, and the 1905 birth cohort study who completed the cognitive and physical tests, and for whom mtDNA copy number were successfully determined,were included in the study. Regarding mortality analysis, information was retrieved from the Danish Death Register.

	No. individuals	Reg. coef. [95%CI]	p-value
Grip strength
Combined	626	0.28 [0.00; 0.57]	0.05
>74 years of age	503	0.29 [−0.05; 0.63]	0.09
>77 years of age	270	0.13 [−0.35; 0.61]	0.59
>80 years of age	207	0.15 [−0.37; 0.68]	0.57
Self-rated health
Combined	873	0.05 [0.01; 0.09]	0.02
>74 years of age	667	0.04 [0.00; 0.09]	0.08
>77 years of age	363	0.02 [−0.06; 0.09]	0.66
>80 years of age	272	0.03 [0.05; 0.12]	0.48
Cognitive composite score
Combined	870	0.07 [−0.05; 0.20]	0.26
>74 years of age	664	0.15 [0.00; 0.30]	0.04
>77 years of age	360	0.12 [−0.09; 0.33]	0.28
>80 years of age	269	0.35 [0.10; 0.60]	0.006
MMSE
Combined	810	0.13 [−0.03; 0.30]	0.12
>74 years of age	663	0.23 [0.02; 0.43]	0.03
>77 years of age	360	0.17 [−0.20; 0.54]	0.38
>80 years of age	269	0.37 [−0.12; 0.87]	0.14
Activity of Daily Living
Combined	831	−0.01[−0.04; 0.02]	0.57
>74 years of age	679	−0.001 [−0.04; 0.04]	0.96
>77 years of age	372	0.02 [−0.04; 0.09]	0.44
>80 years of age	279	0.01 [−0.07; 0.08]	0.85
Mortality
HR lowest vs. highest 2-4 quartilesa
Combined	891	0.82 [0.70; 0.97]	0.02
>74 years of age	681	0.81 [0.68; 0.97]	0.02
>77 years of age	373	0.79 [0.63; 0.99]	0.04
>80 years of age	280	0.73 [0.57; 0.93]	0.01

^alowest quartile (9.68-33.73) vs. highest 2-4 quartiles (33.75-135.87)