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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: DNA Repair (Amst). 2014 Apr 24;19:48–54. doi: 10.1016/j.dnarep.2014.03.027

Figure 2. Recruitment of hMutSα to replicating chromatin.

Figure 2

SETD2 converts H3K36me2 to H3K36me3, which interacts with the hMSH6 PWWP domain to localize hMutSα to chromatin before DNA replication initiates. During DNA replication, nucleosomes are disassembled and the H3K36me3-PWWP interaction is disrupted, releasing hMutSα from nucleosomes. hMutSα readily binds to nascent DNA independent of PCNA, and recognizes newly-formed mismatches to initiate MMR. This image was reproduced from Ref. [15] with permission.